The front section of the New York Times featured two extensive articles on midtown Detroit--one on several small creative enterprises, the other on TechTown, the Wayne State sponsored incubator.
Most of the businesses in the first--Leopold's Books, Good Girls Go to Paris, The Bureau of Urban Living and the excellent Burton Theatre are all within walking (!) distance of one another. Leopold's specializes in graphic novels, Good Girls has a great, diverse bustling vibe, and The Burton shows great off beat films.
To read more on the entrepreneurs